Thomas Murphy - Industrial Statistical Consultant

 

Work History

2009 - Present
Senior Consultant
D.H. Gold Associates, Inc.
   

Industrial Statistical Consultant

1995 - 2009
Industrial Statistical Consultant
Independent Consultant
   

Independent consultant to the pharmaceutical, chemical, and consumer products industries. Analytical method development / quality control / validation, product fill weight control, analysis of stability studies to recommend shelf life and release limits for drug and consumer products, manufacturing quality control / procesS validation studies, advertising claim support, training courses in statistical applications.

1995 - 2001, 2005
Quality Assurance Statistician (Temporary Employee)

Wyeth-Ayerst Laboratories,

Pearl River, NY

   

Process validation, analytical method validation, specification justification, training.

1990 -

1995

Principal Research Statistician

American Cyanamid Company, Agricultural Research Division, Princeton, NJ

   

Internal statistical consultant in support of Agricultural Group operations, including research/development, analytical method development, animal drug safety / efficacy studies, and manufacturing.

1982 - 1990

American Cyanamid Shulton (Consumer Products)

Research Division,

Clifton, NJ

 

1987 - 1990 

Principal Research Statistician
Internal statistical consultant in support of all Shulton Group operations, including research/development and manufacturing.

 

 

1984 - 1987           

Supervisor, Clinical Laboratory
Supervised 3-5 technicians in conduct of consumer testing operations with responsibility for scheduling, test design, statistical analysis and reporting of all studies.

 

 

1982 - 1984           

Group Leader, Statistical & Information Services
Supervised four professionals and one technician in technical computing, statistics, and standards issuance, supporting consumer products research and development.

 

1967 - 1982

American Cyanamid Shulton (Consumer Products)

Chemical Research Division

Bound Brook, NJ

 

1980 - 1982

Group Leader, Computers, Statistics and Instruments
Supervised 3 to 10 professionals and technicians in technical computing, statistical, and instrumentation services.

 

1978 - 1980

Senior/ Principal Research Statistician
Internal statistical consultant with technical supervision of a second statistician in support of all Organic Chemicals Division functions in Bound Brook and Corporate HQ, with emphasis on environmental regulations.

 

1974 - 1978

Group Leader, Automation and Statistical Analysis
Supervised 3-4 professionals in computer control and statistical consulting projects.

 

1971 - 1974              

Group Leader, Computer Control
Supervised 2-3 engineers in design, implementation, and maintenance of computer control projects for chemical processes at Bound Brook plant.

 

1967 - 1971

Statistician
Internal statistical consultant in support of R&D and manufacturing functions of the Organic Chemicals Division.

1962 - 1967
Control Laboratory Supervisor

Hercules, Incorporated , Parlin, NJ

 
Supervision of plant control laboratory (30+ lab operators and technicians) for polyethylene and acetic acid plants, plus plant troubleshooting and customer complaint calls.
1960 - 1962
Process Development Engineer

Hercules, Incorporated , Parlin, NJ

 

Plant troubleshooting and process development in support of polyethylene manufacturing.

1959 - 1960
Production Shift Supervisor

Hercules, Incorporated , Franklin, VA

  Supervised shift operations (seven operators) of a chemical manufacturing plant.
1957 - 1959
Pilot Plant Engineer

Wilmington, DE and Savannah, GA

 
Operated and supervised bench-scale and pilot-scale operations for new products in thermoplastics, insecticides, and paper chemicals.

 

Education

 

  1957

Bachelor of Science - Chemical Engineering       

University of Maryland
  1964
Master of Science - Applied Statistics
Rutgers University
  1965 - 1969

Completed course work for Ph.D. program in Applied Statistics

Rutgers University

 

 

Professional and Honorary Society Memberships:

  1. American Society for Testing and Materials - Fellow 1997
    • Officer of E11 Committee on Quality & Statistics
    • Chair, (2002-2003), Vice Chair (1996-2001, 2004-2005), Secretary (1992-1996)
    • Chair of E11.03 Subcommittee on Stat. Analysis and Control Tech. (1987-1997)
    • C hair of E11.70 Subcommittee on Editorial/Terminology (2002-2008)
    • Chair of E11.30 Subcommittee on Statistical Quality Control (2008-2009)
    • Chair of E11.20 Subcommittee on Test Method Evaluation and Quality Control (2010-present)
    • Committee E02 on Terminology – Member (2004-2007)
    • Committee E55 on Manufacture of Pharmaceutical Products – Member (2004 – present)
    • Award of Merit 1997
    • Frank W. Reinhardt Award (Terminology) 2008
  2. American Society for Quality - Fellow 1987
    • US TAG to ISO/TC 69 / Z1 Statistics – member (2003-present), Vice Chair 2007-2008
    • Chemical Division, Chair (1982-83), other offices (1978-82)
    • Editorial Review Board Quality Progress (1983-89)
    • Technometrics Management Committee (1984-86)
    • Publications Review Board (1983-91)
    • Ellis R. Ott Award (Metro Section ASQ) 2001
  3. American Statistical Association - Member
    • Member, Youden Award Committee (1991-93, 1997-2003)
    • New Jersey Chapter Symposium Committee (1995-98)
  4. American Institute of Chemical Engineers - Member
    • Chair of New Jersey Section, (1969-70)
  5. Sigma Xi , national research society - Member
  6. Alpha Chi Sigma, national chemistry fraternity - Professional Member.

Publications:

  • "Design and Analysis of Industrial Experiments", Chemical Engineering, 48, 168-182 (1977).

  • "Experimental Design and Analysis", Chapter 13,  Applied Techniques in Statistics for Selected Industries, H. E. Hill and J. W. Prane, eds., Wiley, (1984).

  • "Experimental Design for Process Variability", with K. Sears, Transactions of the 39th Annual Quality Congress, American Society for Quality Control, 374-384 (1985). 

  • "Long and Short Range Precision in HPSEC", with L. Papazian, Journal of Liquid Chromatography, 13:1, 25-49 (1990).

  • "Analysis of Antiperspirant Efficacy Test Results", with M. Levine, Journal of the Society of Cosmetic Chemists, 42:3, 167-197 (1991).

  • "The Application of Response Surface Methodology to Sterilization Process Development and Validation of a Water Cascade Autoclave", with J. Hokes, T. Green and A. Cundell, PDA Journal of Pharmaceutical Science and Technology, 53:2, 83-94(1999).
  • "Statistical Process Control and Process Capability", with M. Utter and S. Singh, Encyclopedia of Pharmaceutical Technology, (2003)
  • "Response Surface Methodology for Validation of Oral Dosage Forms", Chapter 6, Pharmaceutical and Medical Device Validation by Experimental Design, L. Torbeck, ed., Informa Healthcare, (2007)
  • "Reporting Test Results – Determining Significant Digits and Rounding Properly", with P. Fortini, ASTM Standardization News, September/October 2008.
  • "Dealing with Outliers", with A. Lau, ASTM Standardization News, November/December 2008.

Papers Presented at Scientific Meetings

  • "Ratio Estimation", 29th All Day Conference on QC and Statistics in Industry, (Metropolitan Section, ASQC), Edison, NJ, September, 1977.
  • "Applications in Industrial Experimentation", 6th Annual ASQC Seminar on QC, (Delaware Section, ASQC), Newark, DE, March, 1979.
  • "Factorial Design Tutorial", 31st All Day Conference on QC and Stat in Industry, (Metropolitan Section, ASQC), Edison, NJ, September, 1979.
  • "Test Methodology in the Routine Control Laboratory", 23rd Annual Fall Technical Conference (Chemical Division, ASQC),  Minneapolis, MN, November, 1979.
  • "Experimental Design in Practice", 33rd All Day Conference on QC and Stat in Industry, (Metropolitan Section, ASQC), Newark, NJ, September, 1981.
  • "Experimental Design", ASQC Tappan Zee Section Meeting, January, 1983.
  • "Applications of Experimental Design", 5th Annual Conference on Quality in the Health Care Industries, (Biomedical Division, ASQC), New Brunswick, NJ, April, 1983.
  • "Clinical Testing of Consumer Products", 12th Annual Symposium on Quality Control, (Delaware Section, ASQC), Newark, DE, March, 1985.
  • "Controlling Process Variability", The Second Ellis R. Ott Conference on Quality Management and Statistics in Industry, New Brunswick, NJ March, 1985.
  • "Experimental Design for Process Variability", 39th Annual Quality Congress, ASQC, Baltimore, MD, May, 1985.
  • "Consumer Clinical Testing", 30th Annual Fall Technical Conference, (Chemical Division, ASQC), Charlotte, NC, October, 1986.
  • "Statistical Methods for Clinical Testing", Dermal Clinical Evaluation Society, Newark, NJ, February, 1987.
  • "Using ASTM Standard Practice E 691 for Conducting an Interlaboratory Test Program", Meeting of ASTM Committee C 16 on Thermal Insulation, Hartford, CT, October, 1989.
  • "The Uses and Misuses of Taguchi Methods", Spring Conference, (North Jersey Section, ASQC), May, 1990.
  • "Using ASTM Standard Practice E 691 for Conducting an Interlaboratory Test Program", Meeting of ASTM Committee C 37 on Thermal Analysis, Philadelphia, PA, March, 1992.
  •  "The Application of Response Surface Methodology to Sterilization Process Development and Validation of a Water Cascade Autoclave", WORLDPHARM99, 1999. FTC
  • "The Application of Response Surface Methodology to Sterilization Process Development and Validation of a Water Cascade Autoclave", 48th Annual Fall Technical Conference, (ASQC/ASA), Roanoke, VA, October, 2004.

Company Presentatons:

 

  • "Ridge Regression Explained", American Cyanamid Statistics Seminar, May, 1979.
  • "What's Happening in Quality in the Chemical Process Industry", American Cyanamid Chemical Group SPC Seminar, Newark, NJ, February, 1987.
  • "Design of Experiments Workshop", American Cyanamid Process Development Symposiums, 1980, 1984, 1987, 1991.
  • "Design of Experiments", Presentation and Workshop, American Cyanamid Formulations Symposium, 1982.
  • "Measurement Assurance Workshop", American Cyanamid Analytical Symposium, 1990.
  • "Animal Drug Stability Testing", American Cyanamid Analytical Symposium, 1992.

Company publications:

  • "Statistical Manual for Analytical Chemists", American Cyanamid Publication,
    First Edition (1982), Third Edition (2000).


 

 

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D.H.Gold Associates, Inc. - Consultants

D.H.Gold Associates, Inc. has assembled well skilled professionals to complement Dr. Gold’s background.  Detailed CV’s of each associates are available by following the links below:

 

Daniel H. Gold, Ph.D. - President & CEO

Stanley Alekman, Ph.D. - Analytical Chemistry & Statistics Specialist

William Bennett, M.S., B.S. - Engineering & Manufacturing Specialist

Bao-Shan Huang, Ph.D. - Process Development, Analytical Laboratory Control Specialist

Jeanne Moldenhauer, M.S. - Microbiology Specialist

Eugene Rynkowski, M.S. - Analytical Chemistry Specialist

Eric Sheinin, Ph.D. - Specialist in CMC Sections of NDA, ANDA & DMF Filings

James Shaver, B.S., B.Ch.E - Engineering & Operational Management Specialist

Bernd Dölle, Ph.D. - Aseptic Manufacturing, PDA/FDA Barrier Technology Specialist

Takeo Murakawa, Ph.D. - Drug Development & Regulatory Affairs Specialist

Thomas Murphy, M.S. - Industrial Statistical Consultant

 

DHG Consulting Team with a total of 195+ years in the Pharmaceutical Industry.

 

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